Home / Build / [3.19] Poisonous Concoction Pathfinder | Full Build Guide

[3.19] Poisonous Concoction Pathfinder | Full Build Guide

Intro & build description

The poisonous concoction is a relatively new skill that has been really shining as a great mapping and league starter build. If you want a smooth league start with the ability to breeze through the Atlas, this Pathfinder build will be a perfect choice for 3.19 Lake of Kalandra.

Build Pros

  • Great as a league starter - doesn't require any specific items to work
  • Can clear all map mods
  • Fast map clear
  • The build is not specifically designed as a boss killer, but it can do Shaper, Elder, and guardians with basic life + resistance gear
  • Reflect is not an issue
  • Scales really well with currency investments

Build Cons

  • Getting good cluster jewels will be quite hard very early in the league

Passive tree(s) and Path of Building

[3.19] Skill Tree
PoB Community


Bandits Quest Choice
Kill all bandits

Ascendancy skill points

LabyrinthsSkill point choice
Labyrinth 1Master Toxicist
Labyrinth 2Nature's Reprisal
Labyrinth 3Nature's Adrenaline
Endgame LabyrinthNature's Boon

Skill gem setup


Plague Bearer

Increased Area of Effect Support

Void Manipulation Support

Body Armor

Poisonous Concoction

Awakened Greater Multiple Projectiles Support

Awakened Vicious Projectiles

Awakened Void Manipulation

Awakened Unbound Ailments

Lifetap Support


Increased Duration Support


Spell Totem Support

Multiple Totems Support


Vaal Molten Shell

Blood Rage


Increased Duration Support

2h Weapon


1h Weapon


Offhand weapon / shield

Flame Dash


Defiance Banner

Build uniques / Example rare gear

Tip: Click on the item to view it on PoE Wiki or to view similar rare items in poe.trade


Rare Helmet

Your ideal helmet should have at least 80 life, some resistances and “Nearby Enemies have -x% to Chaos Resistance” mod.

Body Armour

Cherrubim's Maleficence

Great, cheap body armor which works perfectly with this build. Look for one with increased chaos damage mod as close to 80 as possible.


Rare Gloves

Look for rare gloves with high life, some resistance and chance to suppress spell damage.


Rare Boots

Look for rare boots with at least 80 to maximum life, 30% increased movement speed, some resistance and chance to suppress spell damage.

Left Ring

Rare Iolite Ring

Look for rare Iolite ring with high life, chaos resistance and elemental resistance.

Right Ring

Rare Ring with Despair On Hit

Look for a rare ring with life and “Curse Enemies with Despair on Hit, with 32% increased Effect” mod. Chaos resistance or elemental resistances would be great additional mods.


Rare Amulet

We focus on damage mods with our amulet, so look for damage over time multiplier, chaos damage over time multiplier and + 1 to Level of all Chaos/Dexterity Skill Gems mods. Life is a good additional mod to bench craft.

2 of them at the same time should be attainable quite easily after a few days in the league.


Rare Stygian Vise

Look for rare Stygian Vise with high life, chaos resistance and some additional elemental resistances.



Lycosidae is the shield of choice for the build.
With this shield, our hits can’t be evaded and we don’t have to worry about accuracy.


Cluster Jewels

This build uses 3 cluster jewels, 1 large and 2 medium.

On Large cluster look for 8 passives and following mods:

1) Unwaveringly evil
2) Touch of Cruelty
3) Unholy Grace

On Medium clusters look for 4 passives and following mods:

1) Circling Oblivion
2) Flow of Life


Glorious Vanity (Xibaqua version)

Endgame build also uses Glorious Vanity to convert Elemental Equilibrium keystone to Divine Flesh. This keystone helps with damage mitigation, which is also further boosted with Soul of Shakari pantheon.

Make sure your chaos resistance is capped at maximum before you allocate Divine Flesh.


Rare Jewels

On regular rare jewels look for following mods:

1) Chaos damage over time multiplier
2) Attack speed while holding a shield
3) Increased maximum life
4) Chaos / Elemental Resistances
5) Attributes if you are lacking


Flask Setup

Build uses following flasks

1) Divine Life flask with bleed removal
2) Divine Life flask with poison immunity
3) Sulfur Flask with attack speed during flask effect
4) Quicksilver Flask
5) Jade Flask with increased armor during flask effect

Feel free to share your thoughts/experiences/tips about the build in comments section below.

About gems

Always tries to keep up with the game, its ever-changing mechanisms and explain them in understandable manner.

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